A recent study suggests that patients who stop using new slimming jabs like Wegovy and Mounjaro can put back on shed pounds far faster than those who end conventional diet and exercise plans.
Findings released in a leading health publication shows that while obese individuals can lose substantial amounts of their total mass while undergoing treatment, the weight comes back at an estimated rate of nearly a kilo each month upon discontinuation.
"People buying such treatments must be aware of the risk of quick rebound weight gain when the medication ends," cautioned researcher Dr. Susan Jebb.
Such speed of regain suggests a return to original weight within about 18 months.
Analyzing Approaches
The study, which reviewed 37 of studies involving thousands of participants, compared the outcomes of GLP-1 agonists with other pills.
Scientists point out that individuals who shed pounds through lifestyle changes alone typically experience a more gradual weight regain—around 0.1 kg a month—post-intervention.
Explaining the Quick Rebound
Nutrition scientists propose the mechanism of the injections is key to understanding the heightened weight return.
GLP-1 drugs imitate a natural hormone called glucagon-like peptide-1, which moderates appetite.
"Sustained high doses of GLP-1 levels far above than the body's typical production might result in the system to generate a reduced amount of its endogenous GLP-1, and could diminish sensitivity to its actions," explained Dr. Adam Collins, a dietetics expert.
"Discontinuation of this hormone supplement means appetite is uncontrolled, making overeating much more probable."
A Lifelong Disease?
Health authorities advise the jabs for people with weight-linked health risks, accompanied by prescribed lifestyle changes.
Many experts contend that, considering the high risk of weight regain, the therapy is often ongoing.
This opinion is supported by pharmaceutical companies, who note that the results "emphasize the chronic character of obesity," akin to managing conditions like hypertension.
Patient Testimonies
Individuals who have stopped the medication explain a intense return of appetite.
"I experienced a switch flipping and you're instantly ravenous," described one woman.
The struggle is compounded if users have not established lasting dietary or behavioural modifications during treatment.
Widespread Use
Recent estimates suggest that millions of adults in the UK have tried weight-loss jabs in the past year, with desire remaining high.
- Adoption is more common among females compared to men.
- The middle-aged demographic shows the highest level of interest.
- A large proportion obtain the drugs through private prescriptions rather than the NHS.
Finally, experts stress that while the jabs are effective tools for shedding pounds, they are not a magic cure and long-term success hinges on combined lifestyle support.
